ARCC Webinar
Topic of presentation Strategies for fertility preservation of preadolescent boys undergoing cancer treatment: Lessons from animal models
Details In Canada, ~1000 new cases of cancer in children, under the age of 14, are reported every year. Improved oncological treatments currently enable >80% of pediatric cancer patients to survive into adulthood. However, due to the gonadotoxic effects of such treatments, 50-75% of survivors experience azoospermia or oligospermia. With improved cancer survivorship, more attention is needed to address the quality of life in survivors, including future parenting. The objective of this presentation is to provide an overview of state-of-the-art research on advanced reproductive technologies related to the preservation of fertility potential of immature individuals. Using various neonatal and prepubertal animal models, we and others have established a number of experimental strategies to induce maturation of the testis tissue and cells to produce mature sperm. This includes the use of rodent, domestic, and primate animal models to develop transplantation of spermatogonial stem cells, grafting of testicular tissue, in vitro culture of testicular cells and tissue, as well as in vitro assembly of testis organoids from dissociated cells.  In addition to summarizing the current status and future prospects of strategies for the fertility preservation of preadolescent boys, the discussion will include some of the safety and ethical issues related to fertility preservation options.
Date & Time Friday, December 11th, 2020

12:00pm – 1:00pm (EST)

9:00am – 10:00am (PST)

1:00pm – 2:00pm (AT)
Presenter Dr. Ali Honaramooz, University of Saskatchewan
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